Diabetic foot is a serious health condition that places a significant burden on both patients and healthcare systems worldwide. Since 1999, the International Working Group on the Diabetic Foot (IWGDF) has regularly updated its guidelines for the prevention and management of this condition. The latest 2023 guidelines are based on comprehensive literature reviews and expert recommendations, including newly developed guidance on acute Charcot neuro-osteoarthropathy.
Pathophysiology
Diabetic foot disease encompasses a range of conditions, including peripheral neuropathy, peripheral artery disease (PAD), infections, foot ulcers, neuro-osteoarthropathy, gangrene, and amputations.
Foot ulcers, often caused by a combination of peripheral neuropathy and foot deformities, can lead to severe health complications. Neuropathy reduces sensation in the feet, making individuals less aware of injuries. Combined with biomechanical stress and minor trauma, this can result in the development of foot ulcers.

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Prevention
The prevention of diabetic foot ulcers is based on five key principles:
- Education of patients and healthcare professionals
- Regular foot examinations
- Risk stratification and appropriate assessment
- A multidisciplinary approach to care
- Ongoing monitoring and adjustment of management strategies
Individuals at low risk of foot ulceration should undergo a foot examination at least once a year, while those at higher risk require more frequent assessments and targeted interventions.
Diagnosis and Treatment
The diagnosis of diabetic foot disease involves assessing:
- Peripheral neuropathy
- Peripheral artery disease
- The presence and severity of infection
Treatment strategies include:
- Offloading: The use of specialized orthopedic devices and footwear to reduce pressure on affected areas of the foot.
- Infection Management: Appropriate antibiotic therapy and surgical intervention when necessary.
- Vascular Reconstruction: Improving blood circulation in patients with peripheral artery disease to support wound healing and limb preservation.
- Advanced Wound Healing Interventions: The use of modern therapies and technologies designed to promote ulcer healing and improve clinical outcomes.
Organizational Structure
Successful management of diabetic foot disease requires a well-organized healthcare approach involving multidisciplinary teams, standardized clinical protocols, and continuous professional education.

Outcomes and Importance
Implementation of the IWGDF guidelines has been associated with reduced amputation rates and improved quality of life for people living with diabetes. Particular emphasis is placed on adapting the guidelines to local healthcare systems and considering socioeconomic and cultural factors that may influence implementation.
If you're interested in this topic, be sure to read our article: "Hyperbaric Chamber and Treatment of Diabetes Complications – Focus on Wounds and Diabetic Foot".
The guidelines are available through the link https://iwgdfguidelines.org/guidelines-2023/ and serve as an important reference document for healthcare professionals involved in the prevention and treatment of diabetic foot disease. Their ultimate goal is to reduce the global burden of this condition and improve patient outcomes.
Source: IWGDF Practical Guidelines on the Prevention and Management of Diabetic Foot Disease, 2023
© 2023 The International Working Group on the Diabetic Foot (IWGDF)






